Estrogen Side Effects and Their Impact on Mood
Compounded GLP-1 Availability Update
Women showing how different moods and emotions looks like

Table of Contents

Key Takeaways

How Estrogen Influences the Brain

3 Common Mood-Related Side Effects

1. Mood Swings

2. Anxiety

3. Depression

Impact of Hormonal Changes Over Time

Coping and Support Strategies

Frequently Asked Questions

Restore Hormonal Balance with Expert Care in Connecticut!

Key Takeaways

Estrogen interacts with brain chemicals that help regulate mood, memory, and emotional stability.

Fluctuations in estrogen levels can lead to mood swings, irritability, anxiety, or feelings of sadness.

Hormonal changes at different life stages can affect emotional balance, sleep quality, and energy levels.

Ongoing estrogen imbalances may increase the risk of certain mental health concerns, making regular monitoring important.

Healthy habits, stress management, and professional guidance can help maintain emotional well-being during hormonal changes.

Estrogen Imbalances

Estrogen influences many processes in the body, including those linked to mood and emotional balance. Changes in its levels can bring about shifts that affect how a person feels and responds to daily life. These effects can vary from subtle to more noticeable depending on the situation. 

Here are some ways estrogen can shape mood and emotions.

How Estrogen Influences the Brain

Estrogen is more than just a hormone for reproductive health—it plays a big role in how the brain works. It affects how nerve cells talk to each other and helps control emotions, energy, and focus. Changes in estrogen levels can lead to both benefits and challenges for mental well-being, which is why understanding its role is important.

Does Estrogen Make You Tired? 

It depends. Normal estrogen levels do not usually cause tiredness, but when estrogen is low, the body may have less energy, and fatigue can occur due to its role in cell production, ovulation, and overall energy regulation. Many experience that estrogen can make you tired during hormone shifts such as menopause, postpartum, or certain phases of the menstrual cycle.

  • Mood and Stress Impact: Estrogen plays a role in regulating brain chemicals that influence motivation and mental stamina. Low levels can drain emotional energy, making even simple tasks feel more exhausting. Over time, this mental strain can contribute to persistent feelings of tiredness.
  • Disrupted Rest Cycles: Estrogen works in balance with progesterone to help regulate energy and sleep patterns. When this balance is disrupted—such as when progesterone drops too quickly or estrogen levels shift—energy production and rest cycles can be affected. In these cases, estrogen can make you tired by contributing to daytime drowsiness, mood changes, and difficulty staying alert.

Does Estrogen Make You Sleepy?

Estrogen doesn’t directly cause sleepiness, however, since it regulates sleep patterns and overall rest, fluctuations in its levels can affect the ability to relax. Changes in estrogen levels can influence how easily a person falls asleep and stays asleep through the night. Many notice that estrogen can make you sleepy during certain hormonal phases, such as perimenopause, pregnancy, or postpartum recovery.

  • Hormonal Impact on Sleep Cycles: Estrogen helps regulate the body’s internal clock, which influences the sleep-wake cycle. When levels are stable, it supports deeper and more consistent sleep. Fluctuations can disrupt this rhythm, leading to drowsiness during the day.
  • Sleep Quality Changes: Estrogen affects how long and how well the body stays in restorative sleep stages, particularly during the menopausal stage characterized by fragmented sleep. Poor quality sleep may leave a person feeling unrefreshed in the morning. Over time, these disturbances can cause ongoing tiredness and reduced alertness.
  • Nighttime Discomfort: Low estrogen, especially during menopause, can contribute to night sweats, hot flashes, or restlessness that interrupt sleep. Each interruption can shorten total rest time and increase daytime sleepiness. Addressing these disruptions can improve energy and focus.
  • Disrupted Sleeping Patterns: Estrogen works alongside hormones like melatonin and progesterone, which also influence sleep. For example, lower estrogen levels make women more irritable, and therefore, find it harder to relax. Estrogen can make you sleepy in cases where hormonal interactions make it harder to maintain steady energy levels during the day.

3 Common Mood-Related Side Effects 

Estrogen plays a big role in how the brain manages emotions. When estrogen levels change, it can lead to noticeable mood and emotional shifts. These side effects of estrogen can vary from mild to more disruptive, depending on the person’s overall health, lifestyle, and other hormone levels.

1. Mood Swings

Mood swings are one of the most common emotional changes linked to shifts in estrogen. They can happen suddenly and feel hard to control. These rapid changes can be confusing and exhausting. Over time, frequent mood swings can affect focus, daily routines, and interactions with others.

Changes in estrogen during the menstrual cycle, pregnancy, or menopause can trigger mood changes because of how the hormone interacts with brain chemicals. Hormonal ups and downs may cause the brain to release more or less of certain mood-related chemicals. This can create a cycle where emotions feel more intense or harder to regulate.

2. Anxiety

Estrogen is known to intensify anxiety, and when estrogen levels are elevated, this can contribute to—or even trigger—the onset or worsening of obsessive compulsive disorder (OCD) symptoms. This can cause difficulty concentrating on tasks or fully relaxing.

Anxiety can also make it harder to sleep, especially if the mind feels overactive at night. Poor sleep can increase stress hormones, which in turn can make anxiety worse. Over time, this pattern may lead to a cycle of tiredness and heightened worry.

3. Depression

Estrogen helps regulate serotonin, a chemical that affects mood. Lower or unbalanced estrogen levels can sometimes lead to feelings of sadness or hopelessness. Activities that once felt enjoyable may no longer bring the same pleasure.

Growing evidence indicates that fluctuations in estrogen levels in women can play a significant role in increasing the risk of depression. When such depression arises from physiological or pathological changes in estrogen and progesterone levels, it is referred to as female depression.

Impact of Hormonal Changes Over Time

Hormonal changes happen at different stages of life, and shifts in estrogen levels can bring both physical and emotional effects. These changes can influence mood, energy, and even how the body reacts to daily stress. Understanding how estrogen works in each stage can help someone know what to expect and when to seek support.

Puberty

During puberty, the body increases estrogen production to support reproductive development, a time closely linked to both emotional and hormonal changes. This rise in estrogen can influence mood, energy, and overall emotional responses. For some, higher estrogen during this stage may also lead to changes in sleep patterns and mood stability.

  • Mood Swings: During puberty, rising levels of estrogen and testosterone activate receptors in the limbic system, which can heighten sex drive and contribute to greater emotional volatility and impulsive behavior in adolescents. Researchers have also studied how shifts in the brain’s reward sensitivity during this stage play a role in these changes.
  • Increased Sensitivity: Emotional responses can become stronger, making everyday situations feel more impactful. School stress, friendships, and social interactions may feel heavier than before. Estrogen fluctuations can amplify both uplifting and challenging emotions.
  • Sleep Changes: Hormonal shifts can disrupt normal sleep cycles, making it harder to fall asleep or stay asleep through the night. This lack of rest can affect mood, focus, and energy the next day. As hormone levels stabilize, sleep patterns often become more consistent.

Menstrual Cycle Phases

Estrogen levels naturally rise and fall during the menstrual cycle, and these changes can bring mood and energy shifts. 

  • Follicular Phase: Higher estrogen levels often support better mood and energy. People may notice they feel more motivated and socially engaged during this time. This phase can be a good time for activities that require focus and creativity.
  • Ovulation: Estrogen peaks, which may lead to feeling more energized and positive. Increased estrogen at this point can also boost confidence and physical stamina. Many notice better communication and social interaction skills during this phase.
  • Luteal Phase: Estrogen drops, and this can bring tiredness, irritability, or mood changes. Lower hormone levels may also increase cravings for comfort foods, which can affect energy levels further. Some may experience difficulty concentrating during this time.

Pregnancy and Postpartum Periods 

Pregnancy brings a major increase in estrogen, which helps the body prepare for the baby’s growth and delivery. However, changes can also lead to side effects of estrogen that impact emotions and energy. After birth, estrogen levels drop quickly, which can affect mood stability.

  • Pregnancy Benefits: Higher estrogen supports blood flow, energy, and mood balance for many. It also helps in developing the baby’s organs and maintaining a healthy pregnancy environment. These changes can improve overall well-being, though symptoms like tiredness can still occur.
  • Postpartum Drop: A sudden decrease in estrogen can cause sadness, anxiety, or mood swings. This hormonal shift may also contribute to postpartum depression in some individuals. Support from healthcare providers can help manage these changes effectively.
  • Sleep and Energy: Hormonal shifts, combined with newborn care, can lead to exhaustion. Frequent night waking and feeding schedules add to the challenge of maintaining energy levels. Recovery time varies for each person, depending on both physical healing and emotional adjustment.

Perimenopause and Menopause

Perimenopause and menopause are stages where estrogen levels drop over time, leading to changes in mood, sleep, and overall well-being. Many people consider the benefits of estrogen replacement therapy during this stage to ease symptoms.

  • Mood Fluctuations: Lower estrogen during this stage can lead to irritability, sadness, or heightened stress. These emotional changes may strain relationships, impact work performance, and lower self-confidence. Finding ways to manage stress and maintain emotional support can help improve balance.
  • Sleep Disruptions: Hormonal changes in perimenopause and menopause can make it harder to fall asleep or stay asleep. Night sweats and hot flashes often interrupt rest, making deep, restorative sleep difficult. Over time, ongoing poor sleep can contribute to fatigue and reduced concentration during the day.
  • Energy Changes: A drop in estrogen can cause some to feel consistently tired. Declines in muscle mass and metabolism during menopause can reduce physical endurance and stamina. Staying active, eating nutrient-rich foods, and maintaining a balanced routine can help support energy levels.
Coping and Support Strategies

Coping and Support Strategies

Practical lifestyle habits and emotional support can make it easier to manage mood and energy changes linked to estrogen.

Consistent Medical Monitoring

Regular health check-ups are essential when managing estrogen-related changes. Professional monitoring can help detect early signs of hormonal imbalance and guide treatment options.

  • Routine Hormone Testing: Identifies changes in estrogen levels before they cause major symptoms. Early detection allows for quicker adjustments in treatment or lifestyle. It can also help prevent side effects of estrogen from becoming more severe.
  • Personalized Care Plans: Helps ensure any treatment, such as hormone replacement, is safe and effective. A tailored plan considers overall health, family history, and current symptoms. This approach often results in better outcomes and fewer complications.
  • Risk Management: Reduces the chances of side effects of estrogen leading to long-term complications. Ongoing medical supervision helps identify subtle changes that might be missed otherwise. By catching these early, potential health risks can be addressed promptly.

Lifestyle Adjustments (Exercise, Diet, Sleep)

Daily habits play a major role in balancing hormones and maintaining emotional health.

  • Regular Physical Activity: Supports hormone balance, boosts mood, and reduces stress. Exercise increases the release of endorphins, which improve emotional well-being. It can also help with energy levels, reducing the feeling of constant fatigue.
  • Balanced Diet: Eating nutrient-rich foods can help stabilize energy and mood, making it easier to maximize the benefits of estrogen replacement therapy. Nutrients like omega-3 fatty acids, magnesium, and B vitamins play a role in hormone regulation. Consistent, balanced meals may help reduce mood swings and improve overall vitality.
  • Quality Sleep: Good sleep habits are important, especially when hormonal changes make rest harder to achieve. Going to bed at a regular time and limiting screen use before sleep can improve restfulness. Better sleep supports emotional stability and helps reduce irritability during the day.

Stress Management Techniques

Managing stress is important for keeping both emotions and hormones in check.

  • Mindfulness and Relaxation: Practices like meditation, breathing exercises, or yoga can reduce tension. These activities encourage the body to activate its relaxation response. Over time, this can improve both mental clarity and emotional control.
  • Time Management: Planning ahead and setting realistic goals can lower stress levels. Organizing tasks helps prevent feeling overwhelmed and rushed. This structure can provide a sense of control during periods of hormonal change.
  • Creative Outlets: Hobbies such as art, music, or gardening can boost mood naturally. Engaging in enjoyable activities helps shift focus away from stressors. These outlets also give a sense of accomplishment and joy, supporting overall emotional health.

Professional Help and Therapy Options

When lifestyle changes alone are not enough, professional support can be highly effective.

  • Counseling or Therapy: Offers tools for handling mood changes and emotional stress. A trained professional can provide coping strategies tailored to the individual’s needs. Regular sessions can lead to better understanding and management of emotional patterns.
  • Medical Treatment: In some cases, options like hormone therapy may be considered. For some, the benefits of estrogen replacement therapy can include improved mood, better sleep, and reduced hot flashes. A doctor can determine the right type and dose to minimize risks.
  • Support Groups: Connecting with others going through similar experiences can provide reassurance and practical advice. Group discussions often make people feel less isolated. They can also be a valuable source of tips for managing both physical and emotional challenges.

Frequently Asked Questions

Can too much estrogen cause bleeding? 

Yes, too much estrogen can cause irregular or heavy bleeding. Hormones such as estrogen and progesterone help regulate the menstrual cycle, including the flow and intensity of menstrual periods. High estrogen levels can overstimulate the lining of the uterus, leading to spotting or prolonged periods. This is more likely to happen when estrogen is not balanced with enough progesterone. Monitoring hormone levels and working with a healthcare provider can help prevent this side effect.

What is the most common side effect of estrogen?

The most common side effect of estrogen is breast tenderness. This happens because estrogen stimulates breast tissue growth and increases fluid retention. Some may also notice mild swelling or soreness in the breasts during hormone therapy. These symptoms often improve as the body adjusts to the hormone levels.

Does estrogen impact bowel movements?

While the exact reason for irritable bowel syndrome (IBS) remains unclear, research suggests a link between high estrogen levels and constipation. Estrogen—along with progesterone—can influence IBS symptoms by affecting how the intestines function and altering pain sensitivity. Cells in the gut have specialized receptors for these hormones, allowing the digestive system to detect and respond to changes in hormone levels. 

What are the symptoms of too much estrogen in the body? 

Too much estrogen can cause symptoms such as bloating, breast tenderness, mood swings, and irregular bleeding. Some may also experience headaches, weight gain, or fatigue. Long-term high estrogen levels can increase the risk of certain health issues. Identifying the cause and balancing hormone levels is important for overall health.

What happens when you take estrogen and progesterone together?

When taken together, estrogen and progesterone help balance each other’s effects on the body. Progesterone can protect the uterine lining from overgrowth caused by estrogen, lowering the risk of endometrial cancer. This combination is often used in hormone replacement therapy for those who still have a uterus. It can also help reduce symptoms like hot flashes, mood swings, and irregular bleeding.

Restore Hormonal Balance with Expert Care

Restore Hormonal Balance with Expert Care in Connecticut!

BioRestore provides advanced hormone health solutions in Connecticut to help bring the body back into balance. With a focus on safe and effective treatments, our team addresses the changes that come with hormonal shifts such as perimenopause, menopause, and other life stages. Our approach in Connecticut combines medical expertise with personalized care to support improved mood, better sleep, and sustained energy. 

Take the next step toward restoring balance—contact BioRestore in Connecticut today to schedule a consultation!